Last edited by Moogujas
Monday, May 18, 2020 | History

4 edition of Receptor-Mediated Targeting of Drugs (Nato a S I Series Series a, Life Sciences) found in the catalog.

Receptor-Mediated Targeting of Drugs (Nato a S I Series Series a, Life Sciences)

G. Gregoriadis

Receptor-Mediated Targeting of Drugs (Nato a S I Series Series a, Life Sciences)

by G. Gregoriadis

  • 296 Want to read
  • 12 Currently reading

Published by Plenum Publishing Corporation .
Written in English

    Subjects:
  • Cell Receptors,
  • Pharmacology,
  • Medical / Nursing,
  • Congresses,
  • Drug receptors,
  • Drug targeting,
  • Liposomes,
  • Receptors, Drug

  • Edition Notes

    ContributionsA. Trouet (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages491
    ID Numbers
    Open LibraryOL9655629M
    ISBN 100306418312
    ISBN 109780306418310

    Author(s): Gregoriadis,Gregory; NATO Advanced Study Institute on Receptor-Mediated Targeting of Drugs,( Ákra Soúnion, Greece); North Atlantic Treaty Organization. Scientific Affairs Division. Title(s): Receptor-mediated targeting of drugs/ edited by G. Gregoriadis. However, the number of drugs that act on these targets is relatively small compared to drugs that target proteins and nucleic acids. Further Reading. Drugs, their targets and the nature and number of drug targets: Nature Reviews Drug Discovery, , 5, pp The Druggable Genome. Nature Reviews Drug Discovery, , 1, pp

    Most drug effects are induced by the interaction of a drug molecule with specific molecular structures in the. body known as receptors. 1. However, some drug effects are non–receptor mediated and are caused by the particular physical or chemical properties of the drug molecule. To firmly grasp the concepts of how effects, both desired andFile Size: 1MB. Welcome to TARGET - an easy to use Antimicrobial Reference Guide to Effective Treatment for canine and feline ranks the in vitro efficacy of 24 antimicrobials against 12 of the most common pathogens found in small animal infections to assist you in selecting the most appropriate antimicrobial and dosage for maximum efficacy and minimum toxicity.

      Receptors as Drug Targets 1. Receptors as Drug Targets Capt. Htet Wai Moe 1 2. INTRODUCTION Drugs produce their therapeutic effects • by producing biochemical/ physical changes in the target tissues • of the host • of the organisms which invade the host. 2 3. Here, we report the size and the bioconjugation effects of antibody-conjugated mesoporous silica nanoparticles (MSNs) on in vitro and in vivo targeting ability to BMECs. For this, Ri7 antibody was conjugated to MSNs of two different sizes (50 nm and nm Cited by: 7.


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Receptor-Mediated Targeting of Drugs (Nato a S I Series Series a, Life Sciences) by G. Gregoriadis Download PDF EPUB FB2

This book, containing the proceedings of the 2nd NATO ASI "Receptor-Mediated Targeting of Drugs" held again at Cape Sounion, Greece during 20 June-l Julydeals with drug delivery through systems possessing ligands which can recognize and interact Receptor-Mediated Targeting of Drugs book receptors on the target's surface.5/5(1).

This book, containing the proceedings of the 2nd NATO ASI "Receptor-Mediated Targeting of Drugs" held again at Cape Sounion, Greece during 20 June-l Julydeals with drug delivery through systems possessing ligands which can recognize and interact with receptors on the target's surface.

Receptor-Mediated Targeting of Drugs. Editors: Gregoriadis, G. (Ed.) Usually dispatched within 3 to 5 business days. Conventional attempts to control cell behaviour and function are often marred by the toxicity of the drugs used, their premature waste or inactivation or by their inability to interact with or reach target sites efficiently.

NATO Advanced Study Institute on Receptor-Mediated Targeting of Drugs ( Ákra Soúnion, Greece). Receptor-mediated targeting of drugs. New York: Plenum Press, © (OCoLC) Online version: NATO Advanced Study Institute on Receptor-Mediated Targeting of Drugs ( Ákra Soúnion, Greece).

Receptor-mediated targeting of drugs. Electronic books Conference papers and proceedings Congresses Congrès: Additional Physical Format: Print version: NATO Advanced Study Institute on Receptor-Mediated Targeting of Drugs ( Ákra Soúnion, Greece).

Receptor-mediated targeting of drugs. New York: Plenum Press, © (DLC) (OCoLC) Material Type. Introduction This book elaborates on various aspects of targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases.

Targeted delivery relies on two basic approaches, passive and active targeting. Some receptors have been reported to be highly expressed on both BBB and glioma, which provide the cascade-targeting sites for receptor-mediated drug delivery by: Cellular uptake of drugs bound to a targeting carrier or to a targetable polymeric carrier is mostly restricted to receptor-mediated by: Receptor-Mediated Targeting of Drugs Edited by G.

Gregoriadis Royal Free Hospital School of Medicine London, England G. Poste Smith Kline & French Laboratories Philadelphia, Pennsylvania J. Senior Royal Free Hospital School of Medicine London, England and A. Trouet International Institute of Cellular and Molecular Pathology and Universite.

The development of receptor‐targeted therapeutic agents has been initiated primarily to limit the distribution of toxic drugs to only the pathologic cells, thus Cited by: 6. Receptor-mediated drug delivery can also enable otherwise membrane-impermeable drugs to enter target cells by receptor-mediated endocytosis, or it can induce desirable changes in cell behavior by.

Transferrin receptor–mediated targeting of anticancer drugs Transferrin is a serum glycoprotein and its function is to transport iron through the bloodstream and into cells. It binds to transferrin receptors and causes iron cell internalization through an endocytosis-mediated process.

The facilitation of the binding of the drug –carrier to target cells through the use of ligands or engineered homing device to increase receptor mediated localization of the drug and target specific delivery of drug is referred to as Active Targeting.

drugs that activate, or stimulate receptors, triggering a response It has affinity of binding and ability to produce effect (Intrinsic activity) as well. What is an antagonist. Ligand-receptor-mediated active targeting drug delivery systems have received much attention in recent years [1, 2].

However, studies about the interactions between drug and target molecules have. One way to actively target solely diseased tissue in the body is to know the nature of a receptor on the cell for which the drug will be targeted to. Researchers can then utilize cell-specific ligands that will allow the nanoparticle to bind specifically to the cell that has the complementary receptor.

1 Introduction. Receptor‐mediated targeting is a well‐established method to enhance drug delivery vehicle (DDV) accumulation within specific tissues. 1 Much emphasis, over the past few decades, has focused on the therapeutic potential of treating both solid tumors and circulating tumor cells (CTCs).

2 Targeted DDVs demonstrated enhanced tumor internalization, diagnostic imaging, and Cited by: 8. Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane (invagination).This process forms vesicles containing the absorbed substances and is strictly mediated by receptors on the surface of the cell.

In this review, recent progress on receptor-mediated drug delivery systems targeting glioma is summarized according to the amount and type of the targeting moieties. Single Ligand-Modified Targeting Systems The single ligand-modified drug delivery. Targeted delivery of chemotherapeutic drugs to the desired lesion sites is the main objective in malignancy treatment, especially in highly metastatic malignancies.

However, extensive studies around the world on traditional targeting strategies of recognizing either overexpressed receptors or microenvironments in tumors show great limitations, owing to the off-target effect and tumor Cited by:.

Find helpful customer reviews and review ratings for Receptor-Mediated Targeting of Drugs (NATO Asi Series: Series A: Life Sciences) at Read honest and 5/5.Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis Abstract: Superparamagnetic iron oxide nanoparticles have been used for many years as magnetic resonance imaging contrast agents or in drug delivery applications.Book Description.

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice.